Epicatechin is one of the more exciting ingredients in PUMP, a naturally occurring plant compound with genuine research behind its role in supporting muscle growth signalling. Here's what it is and how it fits into the formula.
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What Is Epicatechin?
Epicatechin is a flavanol, a naturally occurring plant compound, found in cocoa, green tea, and certain fruits. It's one of the main reasons dark chocolate gets talked about as having benefits beyond a treat, and in recent years it's picked up specific interest in strength and sports nutrition circles for a different reason: research suggesting it may influence myostatin, a protein that puts a natural brake on muscle growth. It's included in PUMP at 300mg per serving.
Epicatechin And Myostatin
Myostatin is a protein the body produces to limit how much muscle tissue grows, effectively a built-in ceiling. Animals and humans with naturally low myostatin levels tend to carry noticeably more muscle mass, which is what made this ingredient interesting in the first place. A proof-of-concept study looked at exactly this.1 In mice, two weeks of epicatechin produced an 18% reduction in myostatin and a 30% increase in follistatin (a protein that counteracts myostatin) in older animals. In a small human trial, participants taking 150mg daily showed improved myostatin-to-follistatin ratios (follistatin up 49.2%, myostatin down 16.6%), alongside a 7% increase in hand grip strength, an encouraging early signal for a compound that's easy to include in a formula at a meaningful dose.
Why It's In PUMP
PUMP includes 300mg of epicatechin per serving, double the dose used in the human research above. It sits alongside L-Citrulline, Pine Bark Extract, and AstraGin®, ingredients aimed at blood flow and nutrient delivery, epicatechin is the ingredient in the formula aimed at the longer-term training adaptation side, working through a genuinely interesting mechanism with real science behind it.
Epicatechin FAQs
Not really. Dark chocolate contains epicatechin, but in inconsistent and generally much lower amounts than a dosed supplement, plus sugar and fat you probably don't want alongside your training nutrition.
300mg per serving, double the dose used in the human research behind its myostatin and follistatin effects.
No, it's not a stimulant and doesn't cause the tingling associated with beta-alanine (which isn't in PUMP anyway). It's a flavanol with a completely different mechanism.
Eddie's take: "I like ingredients that are doing a specific job for a specific reason. Epicatechin's role in muscle growth signalling is exactly that kind of science-first addition, not just something added for the label."
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References
- Gutiérrez-Salmeán, G., Ciaraldi, T. P., Nogueira, L., Barboza, J., Taub, P. R., Hogan, M. C., Henry, R. R., Meaney, E., Villarreal, F., Ceballos, G., & Ramírez-Sánchez, I. (2014). Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. Journal of Nutritional Biochemistry. PMID: 24314870.
This article is for informational purposes and is not medical advice. Consult a healthcare professional before starting any new supplement, particularly if you have an existing health condition, are pregnant or breastfeeding, are under 18, or are sensitive to stimulants.